Perspectives in Medical Research

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Apoptosis is a tightly regulated form of programmed cell death essential for tissue homeostasis and genomic integrity. Its dysregulation contributes to diverse pathological conditions, particularly cancer, where evasion of apoptosis enables malignant transformation, tumour progression, immune es…

Introduction: Early clinical exposure (ECE) is an integral component of the competency-based undergraduate medical curriculum in India and can be delivered through different instructional methods. Evidence directly comparing different ECE methods in the same group of studen…

Background: Non-communicable diseases (NCDs) such as diabetes, hypertension, cardiovascular disease, hypercholesterolemia, and cancer are major causes of morbidity and mortality in India, particularly in urban populations. The shift from traditional cereals to refined grains has contributed to u…

Background: Hand eczema is a common inflammatory dermatosis influenced by endogenous susceptibility and environmental exposures. Its clinical and occupational patterns may vary across geographical and occupational settings. Methods: A hospital-based descriptive cross-s…

Background: Volatile substance use (VSU), commonly known as inhalant abuse, is a public health concern, notably among youth in socioeconomically disadvantaged contexts, yet data from India on its medical and psychosocial correlates remain scant. Methods: This cross-sec…

Background: Undernutrition among school-going children remains a major public health challenge in India, particularly in rural communities. Evidence comparing the nutritional status of children attending government and private schools in rural Telangana is limited. Met…

Background: Phlebotomy is a core skill required for safe blood specimen collection in clinical and laboratory practice. This study evaluated the knowledge, attitude and practical competency of BSc Medical Laboratory Technology students after completion of a value-added…

Background: Hepatitis A virus (HAV) and hepatitis E virus (HEV) are important causes of acute viral hepatitis in India. Data on their seroprevalence, demographic distribution, and co-infection with hepatitis B virus (HBV) and hepatitis C virus (HC…

Background: Postoperative sore throat (POST), post-extubation cough and hoarseness of voice are common complications following endotracheal intubation. Topical application of lubricants to the endotracheal tube has been proposed to reduce these airway symptoms, but evi…

Non-neoplastic skin lesions are more prevalent than neoplastic lesions. Clinically, many skin lesions exhibit overlapping morphological features, making correct diagnosis difficult without histopathological evaluation. A pattern-based approach to evaluation of skin pun…

Background: Chronic kidney disease (CKD) is associated with progressive biochemical and haematological changes resulting from declining renal function. Routine haematological parameters and complete blood count (CBC)-derived indices associated wit…

Background: Serum cancer antigen 125 (CA-125) is widely used in the evaluation and triage of adnexal masses. Several hospital-based Indian studies have reported very high diagnostic accuracy for CA-125 in distinguishing malignant from benign ovari…

Introduction: Automated haematology analysers provide red cell indices and graphical distributions that complement blood film examination, which remains essential for identifying morphological abnormalities and mixed cell populations. 
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Introduction: Adhesive capsulitis is a chronic condition marked by inflammation and stiffness of the shoulder joint. This leads to a significant loss of both active and passive movement. While most rehabilitation approaches focus on the glenohumer…

Background: Primary mesenchymal chondrosarcoma is a rare malignant neoplasm originating from bone and soft tissue commonly involving maxilla and mandible, but can also involve ribs, pelvis, femur, and spine. Case report: …

Mixed epithelial and stromal tumor (MEST) of the kidney is a rare, predominantly benign biphasic neoplasm, classically seen in perimenopausal women and often associated with estrogen exposure. Occurrence in young males without hormonal therapy is exceptionally uncommon…

Allergic fungal rhinosinusitis (AFRS) is more commonly implicated worldwide by Dematiaceous fungi, whereas in India, Aspergillus flavus is more frequently identified. Scopulariopsis brevicaulis an uncommon cause of sinonasal disease, with very rare reports o…

Hydatid disease caused by Echinococcus granulosus most commonly involves the liver and lungs; however, primary involvement of atypical anatomical sites is uncommon and often poses diagnostic challenges. This retrospective case series describes four p…

Background: Subcutaneous fungal granulomas are rare deep fungal infections that often mimic neoplastic or inflammatory lesions, making diagnosis challenging, particularly in immunocompetent elderly individuals. Their nonspecific clinical presentat…