Volume: 13 Issue: 2
Year: 2025, Page: 105-111, Doi: https://doi.org/10.47799/pimr.1302.25.3
Received: May 28, 2025 Accepted: May 31, 2025 Published: Aug. 19, 2025
Introduction: Cardiovascular disease is the most common cause of morbidity and mortality in patients with diabetes mellitus, and acute coronary syndrome is more frequent and severe in patients with diabetes. Objectives: This study aimed to compare the angiographic characteristics of diabetic and non-diabetic patients with acute coronary syndrome to gain better insight into the severity of coronary artery disease and comorbidities in both groups. Methods: This retrospective study at the Aster CMI Hospital, Bangalore, included adults (≥18 years) with ACS who underwent coronary angiography. Patients were divided into diabetic and non-diabetic cohorts (68 each) and matched for age, sex, and key comorbidities, excluding those with pre-existing cardiac conditions. Data on demographics, comorbidities, RBS, clinical presentation, and in-hospital outcomes were collected. Coronary lesions were classified as SVD, DVD, TVD, or diffuse, with ≥50% stenosis considered to be significant. Statistical analyses were performed using Student’s t-test and multivariable logistic regression, with P<0.05 deemed significant. Results: The diabetic population had a higher prevalence of comorbidities (P < 0.01), hypertension, chronic kidney disease, and malignancy. CAG positivity (≥50% stenosis) was found in 82.4% of patients with diabetes and 69.1% of patients without diabetes (P = 0.11). The average blood sugar level was higher in diabetics with positive CAG results, but the difference was not statistically significant. Double-vessel disease was the most common disease in both the groups, with no significant difference between them. Conclusion: Patients with Diabetic ACS exhibit a higher comorbidity burden and trends toward more extensive coronary disease. Vigilant diagnostic evaluation, early screening, and individualised management are crucial, particularly given the risk of atypical presentation. Larger prospective multicentre studies including biomarkers, such as HbA1c, are warranted to clarify the impact of diabetes on CAD severity.
Keywords: Acute Coronary Syndrome, Coronary Angiography, Diabetes Mellitus
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©2025 (Teena Paul Skaria) et al. This is an open-access journal, and articles are distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Skaria TP, Priyanka VN, Ankireddypalle O, Hussain S. Coronary Angiographic Features in Diabetic versus Non-diabetic Acute Coronary
Syndrome Patients. Perspectives in Medical Research. 2025;13(2):105-111 DOI: 10.47799/pimr.1302.25.3