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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="Original Article">
  <front>
    <journal-meta id="journal-meta-6dc3490335634f30bcc2067491a0901e">
      <journal-id journal-id-type="nlm-ta">Prathima Institute of Medical Sciences</journal-id>
      <journal-id journal-id-type="publisher-id">Prathima Institute of Medical Sciences</journal-id>
      <journal-id journal-id-type="journal_submission_guidelines">https://www.pimr.org.in/instructions.php</journal-id>
      <journal-title-group>
        <journal-title>Perspectives in Medical Research</journal-title>
      </journal-title-group>
      <issn publication-format="electronic">2348-229X</issn>
      <issn publication-format="print">2348-1447</issn>
    </journal-meta>
    <article-meta id="article-meta-667c5ef1f3084caabb648c7cb5363734">
      <article-id pub-id-type="publisher-id">15</article-id>
      <article-id pub-id-type="doi">10.47799/pimr.0903.15</article-id>
      <article-categories>
        <subj-group>
          <subject>Original Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title id="article-title-81e624cb3d6c4f7daeec9e4c87bd9aba">Non-Invasive Assessment Of Liver Fibrosis In Patients With Non-Alcoholic Fatty Liver Disease In A Tertiary Care Hospital</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name id="name-20ae33e77fb949eda3150d121a91ef74">
            <surname>Ramadoss</surname>
            <given-names>Ishwarya</given-names>
          </name>
          <email>Ishrr13@gmail.com</email>
          <xref id="xref-16554b0d006847149eb9943088260fc3" rid="aff-f0e056fc9a6644c29c79cd889debf633" ref-type="aff">1</xref>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name id="name-09dd961ba2ea41df8438d9540f46a41d">
            <surname>Jayaraman</surname>
            <given-names>Anandaraj</given-names>
          </name>
          <email>dr.anandarajj@gmail.com</email>
          <xref id="xref-f73efa6ef0dc4bc5affbe241f840b9cd" rid="aff-f0e056fc9a6644c29c79cd889debf633" ref-type="aff">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <name id="n-b7bf224197c1">
            <surname>Dhanapal</surname>
            <given-names>Shobana</given-names>
          </name>
          <xref id="x-798bc5a1edef" rid="a-c0d0ff4890c3" ref-type="aff">2</xref>
        </contrib>
        <aff id="aff-f0e056fc9a6644c29c79cd889debf633">
          <institution>Assistant professor, Department of General Medicine, Government Medical College &amp; Hospital</institution>
          <addr-line>Thiruvallur</addr-line>
        </aff>
        <aff id="a-c0d0ff4890c3">
          <institution>Senior Resident,Department of General Medicine, Government Medical College &amp; Hospital</institution>
          <addr-line>Thiruvallur</addr-line>
        </aff>
      </contrib-group>
      <volume>9</volume>
      <issue>3</issue>
      <fpage>64</fpage>
      <lpage>67</lpage>
      <history>
        <date date-type="received">
          <day>28</day>
          <month>10</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>6</day>
          <month>12</month>
          <year>2021</year>
        </date>
        <date date-type="rev-recd">
          <day>21</day>
          <month>11</month>
          <year>2021</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Perspectives in Medical Research is committed to keeping research articles Open Access. Journal permits any users to read, download, copy, print, search, or link to the full texts of these articles, or use them for any other lawful purpose, without financial, legal, or technical barriers subject to proper attribution and ownership of the rights.</copyright-statement>
        <copyright-year>2021</copyright-year>
      </permissions>
      <abstract id="abstract-abstract-title-807fc7f2a5ba4ac9b28eda4143e72352">
        <title id="abstract-title-807fc7f2a5ba4ac9b28eda4143e72352">Abstract</title>
        <p id="paragraph-dd390d2abf8a4118a51f51b85b7de7ed">Aims :To compare the NAFLD fibrosis score and FIBROSIS 4 score to fibroscan, and affirm whether the scores shall be used as a screening tool for liver fibrosis, in place of fibroscan. Methodology: It was a cross-sectional study. Patients with fatty liver on ultrasonological examination with 200 sample size. After obtaining the informed consent the following details were collected socio-demographic details, history, co-morbidities, anthropometric measurements, Laboratory investigations. Results: the ROC curve analysis of fibroscan reveals the area under curve of 0.499 and based on the cut off value of 4.50Kpas the sensitivity and specificity was found to be 85.7% and 83.5% respectively. The ROC curve analysis of fibrosis-4 reveals the area under curve of 0.495 and based on the cut off value of 0.80 the sensitivity and specificity was found to be 91.9% and 92.1% respectively. Analysis of NAFLD fibrosis score reveals the area under curve of 0.476 and based on the cut off value of -1.53 the sensitivity and specificity was found to be 93.1% and 93.9% respectively. Conclusion: Henceforth the study suggests that NAFLD fibrosis score shall be used as a non -invasive bedside assessment of liver fibrosis in high risk population and hence guiding their follow up for prevention of morbidity in resource limited settings.</p>
      </abstract>
      <kwd-group id="kwd-group-7a0342af3c5b42db88f7f3886fe59371">
        <title>Keywords</title>
        <kwd>NAFLD</kwd>
        <kwd>fibrosis</kwd>
        <kwd>fibroscan 3</kwd>
      </kwd-group>
      <funding-group>
        <funding-statement>Nil</funding-statement>
      </funding-group>
    </article-meta>
  </front>
</article>
